Blood Platelet Procedure


What's involved with Blood Platelet procedures? 

Blood platelet procedures include:

  • Concentrated Platelet Rich Plasma (PRP) 
  • Alpha 2 Macroglobulin (A2M)
  • Platelet Lysate (PL)


Procedure Day

On your procedure day, 16-22 vials of blood is drawn from a vein in your arm. This blood is then processed and prepared in our lab for re-injection within 24 hours. We use this blood to prepare an injection of highly concentrated platelets, growth factors and proteins isolated from your blood. 

During a second visit, this PRP is injected under image guidance into the treatment site. 


The PRP, PL and A2M all produce a pseudo-injury in the joint. As a result, expect the joint to be sore for one to three days. Your physician may prescribe pain medicines that will not hinder the healing caused by the procedure. Patients can additionally take Tylenol but are asked to avoid NSAIDs. For the first day after, you should limit activity on the joint.

Most patients report a modest improvement in the first month. You will notice that as time goes on your pain that occurred before is less severe and frequent. Most patients are able to resume light activities after 1 to 3 days. Usually at 2 to 6 weeks patients begin to resume a more vigorous exercise schedule. Most of our very active patients are able to return to their regular routine in 2 weeks and push their performance to higher levels in 2 to 6 weeks. Improvements will continue throughout this time period. Most patients notice continued healing over many months. 

Our outcome data suggests maximum benefit to be seen by 6 months post. Results vary by patient and depend on the condition of the area treated, age, and general health.

The difference between Regenexx’s concentrated PRP and most other PRP is visible. The usual standard fare PRP is reddish in color because it still contains a significant number of red blood cells while Regenexx’s concentrated PRP is amber in color. In addition, Regenexx PRP is more concentrated by a factor of 3X – 5X above what a basic bedside centrifuge machine can produce for physicians. Our in-vitro experiments demonstrate that this produces better tissue healing in tendon injuries and better stimulation of the local stem cells.


Commonwealth Musculoskeletal Medicine
225 Executive Park
Louisville, KY 40207
Phone: 502-771-1012
Fax: 855-347-8216

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